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And have you explored conventional treatment options first

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What’s more, a head-to-head study comparing 500mg and 1,000mg revealed that only the 500mg dose effectively spurred mitophagy, the process of clearing out dead and dysfunctional mitochondria that is central to UA’s potential to improve human health.5 7 As humans age, mitophagy isn’t activated as often or performed as efficiently, meaning that unhealthy mitochondria can build up and lead to chronic diseases like cancer, dementia, and others.8 How 1,000mg is able to provide comparable downstream benefits to 500mg without encouraging mitophagy is somewhat unclear, and more research is definitely needed to further explore this, but it’s one of the reasons we don’t elevate urolithin A supplements with bioavailability enhancers toward the top of our efficacy rankings