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The peptide acts primarily through modulation of the vascular endothelial growth factor (VEGF) pathway and the NO system
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Anti-angiogenic factors include thrombospondin-1, angiostatin, endostatin, vasostatin, tumstatin, interferon-γ, glycosaminoglycan, anti-tissue factor/anti-factor VIIa, and tissue inhibitors of MMPs (Rust et al., 2019)
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