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A specific group of them are analgesic peptides, whose origins date back to the 1970s, when the existence of various subtypes of opioid receptors was confirmed and the first endogenous opioid peptides, enkephalins, were discovered
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ventrata , nepenthesin and neprosin (in a 4:1 rate) displayed high gluten-degrading efficacy and prevented accumulation of IELs in vivo using HLA-DQ8 non-obese diabetic (NOD/DQ8) mice
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