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The peptide appears to interact with the dopaminergic and serotonergic systems, which may contribute to its effects on pain perception and mood
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44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops
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