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Notably, both families of enzymes are positively regulated by ROS (207), a common by-product of inflammatory pathologies, and are upregulated under pathological conditions associated with inflammation, including hypertension (58, 81, 118), diabetes (154, 281), atherosclerosis (105, 127), sepsis (87), obesity (10, 185) and aging (70)
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Wei et al., 2013
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