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Tau oligomers bind to cardiolipin, and this binding leads to the creation of membrane pores, causing mitochondrial swelling, cytochrome c release, and a reduction in membrane potential ( Figure 5 illustrates schematically the processes that eventually lead to Alzheimer’s disease, where the major players are Abeta, phosphorylated tau, and cardiolipin

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[PubMed] [Google Scholar] 156.Thal L.J., Grundman M., Berg J., Ernstrom K., Margolin R., Pfeiffer E., Weiner M.F., Zamrini E., Thomas R.G