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Proposed mechanisms in the literature include Copper delivery: forms stable complex with Cu²⁺ (binding constant log10 ≈ 16.44), delivering copper while silencing redox toxicity and Gene expression: upregulates structural genes (TGF-β pathway) and downregulates inflammatory genes (IL-6, fibrinogen)
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Reduced muscle mass will lead to overestimation of GFR and increased muscle mass will lead to underestimation of the GFR
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