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Tumor microenvironment fibrosis and drug delivery barriers Mechanisms of collagen deposition in the extracellular matrix The activation of CAFs is widely recognized as a major contributor to collagen deposition and cross-linking by producing enzymes such as lysyl oxidase (LOX), thus leading to tissue stiffness in TME [20–22]
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The most recognizable pattern of visual field abnormality in patients with moderate to severe hydroxychloroquine retinopathy (Table 4) is a complete or incomplete ring scotoma, as shown in Figure 6
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