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The data from this registry demonstrates a survival advantage associated with intravenous A1AT administration, which develops independently and decoupled from the FEV1 decline (67)
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Notably, in their HEK293 cell line, Ser363 was constitutively phosphorylated but showed no increase with opioid agonists, and Thr370 could be phosphorylated by stimulation of PKC activity (see below) in addition to DAMGO
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