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(2022) found the top 20 differentially regulated metabolites, namely, 2-imino-1-imidazolidineacetic acid, metyrapone, chlorothalonil, 5-oxo-d-bilirubin, Asp-Lys-Arg-Glu-Lys, gossypol, Phe-Glu-His-Asp, N6-methyladenosine, 3′,4′-methylenedioxyorobol, N-omega-hydroxy-L-arginine, 4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoic acid, linarin, O-desmethylmycophenolic acid, 3b-(1-pyrrolidinyl)-5α-pregnane-11,20-dione, leucoside, D-glutamine (S)-2-hydroxyglutaric acid, and 5-hydroxymethyl-2-furancarboxylic acid metabolites, to be downregulated, and 7-keto-8-aminopelargonic acid, 1-(piperidin-2-yl)propan-1-one, δ-undecalactone, Glu-Pro-Gly-Tyr-Ser, indole-3-lactic acid, Ile-Phe-Val-Lys, 3-hydroxyethylchlorophyllide a, 3-devinyl-3-(1-hydroxyethyl) chlorophyllide a, and methohexital metabolites were found to be upregulated in myocardial diastolic dysfunction of DCM patients with type 2 diabetes, in a study from China (Hao et al., 2022)

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They produce enough in their digestive systems via bacterial fermentation