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although they range in size, the proteins all encode a bZIP domain, and other domains associated with transcriptional activation and ubiquitin-binding, and protein-protein interaction (INT) (Fig

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Since the cloning of the first OR, those models have been superseded by heterologous expression systems (HEK, CHO, COS-7, Xenopus laevis oocyte) in which OR are easily expressed in large amount but whose cellular characteristics are far from neurons in which OR are endogenously expressed