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Simultaneously, NNMT downregulates Hpgd , the gene encoding 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the enzyme responsible for PGE 2 degradation, causing PGE 2 accumulation and establishing a pro-inflammatory milieu [43]

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Similarly, a lactate-to-pyruvate ratio of 6 reported in autistic children is equivalent to a 1500:1 ratio of oxidized NADH to reduced NADH