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Pancreatic α cells were identified by the presence of round dense-core vesicles without any halo, while β cells were characterized by immature secretory granules with light cores and mature secretory granules with dense cores and prominent halos

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Recently, thio/barbiturates have drawn attention in the field of tyrosinase inhibitors 86 , due to their attractive structural unit of β -phenyl- α , β -unsaturated carbonyl scaffold responsible for tyrosinase inhibitory function