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Second, aggresomal targeting of misfolded polypeptides is accompanied by the release of CTIF from the CT complex, resulting in preferential inhibition of CT (Fig

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reported that LKB1 mutation in KRAS mutant lung adenocarcinoma confers a glutamate enriched phenotype in TME, and this feature was associated with CD8 + T cell activation against PD-1, whereas treatment with the glutaminase inhibitor CB-839 inhibited CD8 + T cell expansion and activation