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Recruitment and Eligibility Criteria Participants are recruited during medical visits in the Allergology, Digestive, Internal Medicine, or Dermatology units of Hospital Clínic of Barcelona, based on the following eligibility criteria: age over 18 years, symptoms associated with histamine intolerance in two or more organs or systems, reduced serum DAO activity and/or any of the DAO-encoding gene variants (rs10156191, rs1049742, rs1049793, and s2052129), not having started a low-histamine diet, and not having taken DAO supplementation
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