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In the same study, punicalagin and urolithin A (the main microbiota metabolites of pomegranate ellagitannins) increased tight junction protein expression levels which were decreased by LPS, and they reversed the LPS-induced inflammatory response in Caco-2 cells [75]
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These may resemble vitiligo and often appear on exposed areas, gradually becoming more noticeable and sometimes spreading if the underlying trigger persists over time.3
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