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A double-blind, randomized, placebo controlled crossover trial studying 33 outpatients who had sustained a TBI (ranging from mild to severe) with self-reported sleep disturbance found that compared to placebo, prolonged-release melatonin (2 mg) was associated with improved sleep quality ( P ≤ .0001), but it had no effect on sleep-onset latency ( P = .23)
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Physicians recommend magnetic resonance angiography (MRA) screening for patients with two or more first-degree relatives with a history of cerebral aneurysms
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