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Substitutions at aggregation-prone residues in the central region of the sequence suppress fibril formation, allowing the peptide to remain soluble in standard aqueous research media at physiological pH, a property that pramlintide achieves only at lower pH values
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The details of CaSR allosteric modulation by synthetic drugs is out of the scope of the current review, for a comprehensive explanation refer to these studies (Hannan et al., 2016
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