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They administered a CX3CL1-neutralizing antibody intrathecally and found that blocking fractalkine reversed hyperalgesia and allodynia [107]
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While many of the current studies investigating the effects of SCT on neurodegenerative disorders employ different protocols and cell types, most of them point to neuroprotection mediated by brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), or nerve growth factor (NGF) [25], as shown in Fig
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