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Several candidate non-glutathione disulfide substrates for the dithiol mechanism have been identified using monothiol glutaredoxin mutants as bait proteins for the trapping of Grx(SSR) species (Fig
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Keap1 is a cytoplasmic protein with a Kelch repeat domain for binding NRF2 and a BTB (Bric-a-brac, Tramtrack, Broad complex) domain for binding Cullin3 (Cul3)
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