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Thiamin is essential for turning carbs and amino acids into energy, supporting DNA/RNA production, and fueling the Krebs cycle. Deficiency leads to beriberi, but even low levels may have wide-ranging health impacts.
While so far only selected ABC transporters, including ABCB1 and ABCG2, have been studied for their role in BCL-2 inhibitor transport 66,67 , we investigated all 48 ABC transporters using an unbiased CRISPR/Cas9 screening approach in AML
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iScience 24 , 103440 (2021)
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