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Polyarticular Juvenile Idiopathic Arthritis (pJIA) The approximate incidences of adverse reactions reported in patients 2 to 18 years of age with pJIA treated with oral, weekly doses of methotrexate (5 mg/m 2per week to 20 mg/m 2per week or 0.1 mg/kg per week to 0.65 mg/kg per week) were as follows (most patients were receiving concomitant NSAIDs, and some received corticosteroids): elevated liver function tests, 14%

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Increased risk of cardiovascular diseases Since cardiovascular disease is a leading cause of death in women, monitoring B12 levels is essential, particularly for women with a family history of heart disease or other risk factors like obesity and hypertension