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5 Effects of microgravity on intestinal barrier Microgravity is the predominant characteristic of the space environment, which can induce physiological adaptation and pathophysiological alterations in multiple systems, such as muscle atrophy, bone demineralization, and immune system dysregulation (Nie et al., 2024)

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Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose

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