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While conventional carboplatin doses result in thrombocytopenia in 20-40% of patients and severe neutropenia in less than 20%, high doses can result in life-threatening toxicity, made more manageable by addition of granulocyte colony stimulating factor (GM-CSF)
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Amount:2 Grams
Exposure can provoke chronic immune activation, increase gut and brain permeability, and impair mitochondrial and neurological function¹⁻³
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