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Yong-hui et al., 2021) verified that Naringin can directly inhibit its target gene KIAA1199 by increasing the expression of miR-216a, thereby promoting apoptosis of CRC cells in colorectal cancer
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Molecular substances can also modulate BBB permeability, such as leukotrienes, bradykinin, and adenosine, likely by inducing a temporary inflammatory reaction and improving paracellular permeability [18,103,104]
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