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Responsible short-term use under medical supervision carries low risk, but misuse or prolonged use can lead to tolerance, psychological dependence, and withdrawal symptoms

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In cats receiving gene immunotherapy by the peritumoural administration of histo-incompatible Vero cells expressing human interleukin-2, in addition to surgery and radiation therapy, only five of 16 FISS cats (31%) had FISS recurrence, while eleven of 16 control cats (69%) that only had surgery and radiation therapy, but no immunotherapy, had FISS recurrence within 16 months (Quintin-Colonna et al., 1996)