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They also showed that the podocyte-specific TGF-β1 increase markedly worsened diabetes-induced mesangial matrix expansion, GBM thickening, podocyte foot process effacement, and kidney function impairment in Akita mice
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Mechanistically, suppression of the urea cycle and reduced endogenous polyamine synthesis may conserve PLP, thereby limiting polyamine toxicity and supporting ccRCC proliferation (Fig
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