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All of the mechanisms discussed above have been shown to be present in CKD, namely upregulated NOX activity, eNOS uncoupling, and pro-oxidative activities of myeloperoxidase and xanthine oxidase [7,12]

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These computational models of airway microenvironment may be used to answer research questions, such as, of the targets identified by the molecular systems architecture in Table 1 , which ones will prove more effective in reducing airway inflammation/hyper-responsiveness/remodeling