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Conceptually, hormones may be divided into 2 classes: • Hormones that act predominantly via nuclear receptors to modulate transcription in target cells (e.g., steroid hormones, thyroid hormone, and vitamin D) • Hormones that typically act via membrane receptors to exert rapid effects on signal transduction pathways (e.g., peptide and amino acid hormones) The receptors for both classes of hormones provide tractable targets for a diverse group of compounds that are among the most widely used drugs in clinical medicine

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Research into thymosin beta-4 began in the late twentieth century and led to the development of TB-500 as a synthetic research peptide