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A comprehensive review of its development history and early clinical findings is described here: This publication summarizes: Preclinical metabolic findings Early human safety trials Clinical evaluation in overweight populations Favorable tolerability profile Lack of growth-hormone–mediated side effects While it did not ultimately achieve commercial drug approval, its safety data and selective mechanism remain scientifically relevant
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Unlike other anti-CD38 antibodies, TNB-738 does not induce cell death and immunosuppression, leading to a more balanced immune response
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