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TNF-α inhibitors have long been established for the treatment of JIA, and data for treatment duration of more than 10 years is available confirming its effectiveness and tolerability in children and adolescents [63]
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Established Adjuncts — Clear Indications Hyperbaric Oxygen Therapy (HBOT) Strong evidence specifically for impaired or hypoxic healing: diabetic foot ulcers, irradiated tissue, compromised skin grafts/flaps — HBOT meaningfully reduces amputation risk and improves graft take in these settings
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