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Autophagy blockade with Atg3-knockdown increased mitochondrial ROS in CD4 + cells from Y subjects (Figure 5I)
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Concurrently, SCFAs enhance intestinal barrier integrity by upregulating tight junction proteins (e.g., occludin), which reduces systemic lipopolysaccharide (LPS) leakage and inhibits TLR4/NF-ΞΊB-driven synovial inflammation (24, 25)
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