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Carrier-mediated transport involves the binding of the target molecules to the receptor portion of the transporters, which in turn produces a conformational change in the carrier and allows the translocation of the compound (147)
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R While Gilbert syndrome itself is considered benign, reduced UGT1A1 activity also impairs glucuronidation of drugs (irinotecan toxicity is dramatically increased in UGT1A1*28 homozygotes) and estrogens
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