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Dysregulated SIRT activity impairs mitochondrial function, leading to reduced ATP production, excess ROS, and cell death—all of which contribute to CVD progression [25]
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Additionally, p-values displayed above the 'All models' (green) plots indicate statistical significance between the top-performing dataset and the combined group (HCMI + CCLE), calculated via two-sided Mann-Whitney U-tests with BH correction (lung: p=3.0x10 −6
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