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In a study of 13 patients with ASD, mB12 25–30 µg/kg/day (up to 1500 µg/day, route of administration unknown) given for 6–25 months led to significant improvements in IQ, developmental quotient, and Childhood Autism Rating Scale (CARS) score
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These include modulations in gene expression, stimulation of the endocannabinoid system, and action on the central nervous system
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