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Mechanism of acetaminophen-induced hepatotoxicity. High dose of... | Download Scientific Diagram
First, each possible target for Rg1 could be determined by using the SwissTargetPrediction tool (Our study used SwissTargetPrediction ( Next, genes related to PD could be filtered using the GeneCards database ( These targets were then imported into Cytoscape 3.10 to establish a drug-target-disease network, followed by the construction of a protein-protein interaction (PPI) network using String database ( The PPI network was useful for the selection of targets for further analysis, representing areas with established experimental support
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Results: Compared with the control group, transfection of miR-126 mimics resulted in a decrease in ADAM9 expression and an increase in Mertk expression in M1 macrophages
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