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The IF appears to be species-specific [17]: in dogs it is synthesized by pancreatic tissue and to a lesser extent by the gastric mucosa [17,18,19], while in cats it is synthesized exclusively by pancreatic tissue [18,19,20,21]

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Without a modest calorie deficit, adequate protein, and regular movement, the fragment has far less to work with, because it influences how the body handles fat rather than forcing weight off on its own