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Indirect Evidence of Glutamatergic Abnormalities from Human Studies Though human subjects studies remain inconclusive as to whether grey matter (GM) integrity changes are premorbid risk factors increasing vulnerability to developing PTSD or are acquired post-trauma as signs of psychopathology, substantial data from animal models provide evidence of stress/trauma-induced structural changes, most notably in the hippocampus and medial PFC (for a review see [1, 38])

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