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Environmental factors, including postnatal maternal separation and early-life stress, can also induce expression of depressive-like behaviors at 4 months, as demonstrated by open field and novel object recognition tests (Robinson et al., 2024)
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Inclusion of kinetics (pharmacokinetics, toxicokinetics) in regulatory guidance has been developing across all regulated industry sectors over the last few decades but there is ongoing debate on the opportunities that integration of kinetics provides for dose level selection
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