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3.6 Hepatic Effects While GLP-1R expression in the liver is debated (some studies report low-level expression, others find none), semaglutide exerts significant hepatic effects likely mediated through indirect mechanisms including reduced hepatic lipid delivery (from decreased adipose tissue lipolysis and reduced caloric intake), improved insulin sensitivity (reducing hepatic de novo lipogenesis), and potentially through gut-liver axis signaling
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Specification:5 mg vial
B Bowman, PhD, Div of Diabetes Translation
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