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Wrist Circles: Slowly rotate wrist in circles, 10 each direction, 3 times daily Forearm Stretch: Extend arm, gently pull fingers back, hold 30 seconds Ball Squeeze (light): Gentle squeezes with soft stress ball, 10 reps, 2 times daily Supination/Pronation: Rotate forearm palm-up to palm-down, 15 reps Progressive Loading Phase (Weeks 3-6) As pain decreases and function improves, gradually introduce more challenging exercises

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Metformin reduced levels of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6, inhibited microglial activation and the translocation into the cellular nucleus of NF-κB p65 and the phosphorylation of ERK1/2 and p38 MAPK [98]

and body application.