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CD8+ T-cells secrete IFN-γ, which can reduce SLC7A11 expression, thereby promoting ferroptosis (146)
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140 Thus, cysteine contributes to the inhibition of ferroptosis both as a component of glutathione, which facilitates the scavenging of lipid peroxides by the phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4), and as a substrate of NFS1
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