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The selenophosphate synthetase 2 (SEPHS2), an enzyme in the selenocysteine biosynthesis pathway, is required in cancer cells to detoxify selenide, an intermediate that is formed during selenocysteine biosynthesis (Burk and Hill, 2015)
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Accumulated AGEs bind to membrane receptors on endothelial cells and promote the onset of tissue damage and the activation of the proinflammatory pathway that involves the NFB transcription factor responsible for regulating the expression of other inflammatory cytokines (Figure 4) [37]
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