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Although the E 2 k and E 3 enzyme components of KGDHC (and the E 3 enzyme component of BCKADHC) are thioacylated in kidney mitochondria of rats administered TFEC, the E 2 p (dihydrolipoamide acetyl transferase) and E 3 enzyme components of PDHC are not (Bruschi et al., 1998, James et al., 2002)
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In contrast, another study applying similar methodology in the same database for events between January 2018 and September 2022 reported a significant association of ileus cases with semaglutide (IC 025 3.04 [0.11 lower one-sided 95% CI]), but not for any other GLP-1RAs (94)
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