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During mouse lung development, in the perinatal period, females show higher GPx1 transcription levels than males, suggesting they may be better protected against oxidative stress [116]

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3 Ferroptosis in RCC 3.1 Ferroptosis signaling pathway and RCC 3.1.1 HIF-iron metabolism pathway involved in ferroptosis and RCC ccRCC is associated closely with mutations in the VHL gene that lead to the activation of HIF-1α and HIF-2α via a pseudohypoxia mechanism, resulting in the transcription of genes involved in tumor progression (76)