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However, tumor-associated proteases, such as matrix metalloproteinases (MMPs), matriptase, and urokinase-type plasminogen activator (uPA), will cleave the spacer and remove the masking domain to activate target binding

Cell Migration Research

Number of Vials:3 Vials (Differentiated Results)

This is genuinely notable because it came against the FDA's own staff scientists' recommendation: the agency's briefing documents had proposed the opposite conclusion for all seven peptides under review, citing a lack of quality data supporting safety and effectiveness, and a more fundamental "foundational challenge" — that the FDA can't yet clearly define what these substances even are, given how much variation exists between different suppliers' products sold under the same name